A General Quantitative Genetic Model for Haplotyping a Complex Trait in Humans
نویسندگان
چکیده
منابع مشابه
A General Quantitative Genetic Model for Haplotyping a Complex Trait in Humans
Uncertainty about linkage phases of multiple single nucleotide polymorphisms (SNPs) in heterozygous diploids challenges the identification of specific DNA sequence variants that encode a complex trait. A statistical technique implemented with the EM algorithm has been developed to infer the effects of SNP haplotypes from genotypic data by assuming that one haplotype (called the risk haplotype) ...
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Whether in natural populations or between two unrelated members of a species, most phenotypic variation is quantitative. To analyze such quantitative traits, one must first map the underlying quantitative trait loci. Next, and far more difficult, one must identify the quantitative trait genes (QTGs), characterize QTG interactions, and identify the phenotypically relevant polymorphisms to determ...
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Haplotyping a Quantitative Trait with a High-Density Map in Experimental Crosses
BACKGROUND The ultimate goal of genetic mapping of quantitative trait loci (QTL) is the positional cloning of genes involved in any agriculturally or medically important phenotype. However, only a small portion (< or = 1%) of the QTL detected have been characterized at the molecular level, despite the report of hundreds of thousands of QTL for different traits and populations. METHODS/RESULTS...
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Quantitative traits are often influenced by many loci with small effects. Identifying most of these loci and resolving them to specific genes or genetic variants is challenging. Yet, achieving such a detailed understanding of quantitative traits is important, as it can improve our knowledge of the genetic and molecular basis of heritable phenotypic variation. In this study, we use a genetic map...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2007
ISSN: 1389-2029
DOI: 10.2174/138920207782446179